10/31/25

Between Two Hearts: Psychedelic Promise for Postpartum Depression

As psychedelic research expands, so does the promise of applications across a wide variety of mental health conditions. Approximately one in eight people in the US is diagnosed with postpartum depression, but only one in four exhibiting symptoms received a perinatal mood and anxiety disorder diagnosis, and only half reported receiving mental health care in the first year postpartum. Alternative treatments like psychedelic therapy have not been studied in this population, in part due to the ethical complexities.

Reunion Neuroscience, a biopharmaceutical company, recently released Phase 2 clinical data on RE104, its proprietary psilocybin-like compound, demonstrating a statistically significant reduction in depression scores sustained through a 28-day follow-up. Preliminary findings from a separate lactation study also suggest that breastfeeding or chestfeeding can be safely resumed shortly after treatment with RE104. Lactation studies and studies on birthing parents specifically are exceedingly rare in psychedelics; these results have promising potential for the future of research in this area.

Plant Parenthood will host a webinar with Dr. Camille Hoffman, a site Principal Investigator on Reunion’s trials, to discuss the results of the Phase 2 study, the lactation study and what Reunion hopes to discover about the impact of its psilocybin compound in the future. We will also discuss the broader implications of this research on post partum health and lactating parents.

We will include time for participant Q&A. This webinar will be recorded and sent to all ticket holders who cannot attend live. 

About the Speaker

Dr. Camille Hoffman is a Professor of Maternal Fetal Medicine in the University of Colorado Departments of Obstetrics & Gynecology and Psychiatry. Her clinical expertise is in managing high-risk pregnancies, obstetric ultrasound, and the management of psychiatric conditions during pregnancy and the postpartum period. Her research focuses on interventions to improve maternal mental health in order to improve the overall health and wellness of women and their children. Dr. Hoffman is a founding board member of the Marcé Society of North America and formerly served on the board of the International Marcé society for perinatal mental health as well as March of Dimes Colorado.

Dr. Hoffman completed medical school at the Medical University of South Carolina, obstetrics & gynecology residency at University of Miami, and her maternal fetal medicine fellowship at University of Colorado Anschutz Medical Campus. She also completed a fellowship in Integrative Medicine through the University of Arizona in 2018. Dr. Hoffman lives in the Rocky Mountain front-range with her husband, two elementary-school aged children, many bicycles, and a menagerie of animals.

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Mothers of the Mushroom